RNA binder 2
RNA binder 2 (Compound 20) is a covalent inhibitor targeting the r (CUG) exp RNA in myotonic dystrophy type 1 (DM1) . RNA binder 2 binds to RNA via a Hoechst scaffold, blocking MBNL1 binding and restoring normal splicing. RNA binder 2 is promising for research of DM1[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Smiles
CN1CCN(C2=CC=C3C(NC(C4=CC=C5C(NC(C6=CC=CC(OCCCC(N7CCN(C(C(C)(C)CCl)=O)[C@@H](C)C7)=O)=C6)=N5)=C4)=N3)=C2)CC1
Molecular Formula
C39H47ClN8O3
Molecular Weight
711.30
References & Citations
[1]Springer N A, et al. Discovery of RNA-Reactive Small Molecules Guides Design of Electrophilic Modules for RNA-Specific Covalent Binders[J]. bioRxiv, 2025: 2025.04. 22.649986.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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