Amb929
Amb929 (ZINC000002782982), a nsp3 ligand, is an anti-SARS-CoV-2 agent. Amb929 inhibits SARS-CoV2-mNG replication in VeroE6 cells with an EC50 of 34.7 µM. Amb929 has limited and moderate cytotoxicity for VeroE6 cells (CC50: 281 µM) . Amb929 also inhibits SARS-CoV-2-mNG replication in Human Airway Epithelium (HAE) [1].
Product Specifications
CAS Number
438196-25-9
Product Name Alternative
ZINC000002782982
UNSPSC
12352100
Target
SARS-CoV
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CC(C)COC1=CC(C2=NC3=CC=CC=C3C(C(NC(NC4=CC=C(C(OC)=O)C=C4)=S)=O)=C2)=CC=C1
Molecular Formula
C29H27N3O4S
Molecular Weight
513.61
References & Citations
[1]Mathilde Galais, et al. Highly potent antiviral drug candidates targeting SARS-CoV-2 nsp3 and nsp5. bioRxiv 2025.04.28.650947.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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