IMPDH II/HDAC1-IN-1
IMPDH II/HDAC1-IN-1 (Compound C12) is an orally active dual-target inhibitor of IMPDH II and IMPDH II (IC50 values are 84.69 nM and 81.75 nM, respectively) . IMPDH II/HDAC1-IN-1 has significant anti-tumor activity and has an anti-proliferative effect on K-562 cells (IC50 = 305.31 nM) . IMPDH II/HDAC1-IN-1 exerts a synergistic anti-tumor effect by simultaneously targeting IMPDH II and HDAC1, inhibiting tumor cell proliferation and inducing apoptosis. IMPDH II/HDAC1-IN-1 can be used in the study of cancers such as chronic myeloid leukemia (CML) [1].
Product Specifications
UNSPSC
12352100
Target
Apoptosis; HDAC; IMPDH
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
ONC(CCC1=CC=CC(NC(NC2=CC3=C(C(C4=NCCS4)=CN3C)C=C2)=O)=C1)=O
Molecular Formula
C22H23N5O3S
Molecular Weight
437.51
References & Citations
[1]Deng FB, et al. Design, synthesis and antitumor activity evaluation of novel IMPDH II and HDAC1 dual inhibitor. RSC Med Chem. 2025 May 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
