PZL-A
PZL-A is a activator of mitochondrial DNA (mtDNA) synthesis. PZL-A restores wild-type-like activity to mutant forms of polymerase γ (POLγ) with AC50 s of 160 and 20 nM for A467T and G848S. PZL-A activates mtDNA synthesis in cells, enhancing biogenesis of the oxidative phosphorylation machinery and cellular respiration. PZL-A is promising for relieving POLG disease and other severe conditions linked to depletion of mtDNA[1].
Product Specifications
CAS Number
[3068830-89-4]
UNSPSC
12352005
Target
DNA/RNA Synthesis; Mitochondrial Metabolism; Oxidative Phosphorylation
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=CC2=C1OCC[C@@H]2NC(NC3=NN(C4=CC=CC=C4)C=C3)=O
Molecular Formula
C19H17ClN4O2
Molecular Weight
368.82
References & Citations
[1] Valenzuela S, et al. Small molecules restore mutant mitochondrial DNA polymerase activity. Nature. 2025 Jun; 642 (8067) :501-507.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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