AAK1-IN-8
AAK1-IN-8 (Compound 18) is a pan-NAK inhibitor. AAK1-IN-8 inhibits AAK1 and GAK (EC50 values are 50 and 190 nM, respectively) . AAK1-IN-8 inhibits the phosphorylation of AP2-µ2 subunit at T156[1].
Product Specifications
CAS Number
2969205-90-9
UNSPSC
12352005
Target
AAK1; Cyclin G-associated Kinase (GAK)
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Field of Research
Infection
Smiles
O=C(C1=CC=C2C=C1OCCOCC/N=C3C=CN4N=CC2=C4N\3)NCC5=CC=CC=C5
Molecular Formula
C24H23N5O3
Molecular Weight
429.47
References & Citations
[1]Mensing T E, et al. Development of pyrazolo [1, 5-a] pyrimidine based macrocyclic kinase inhibitors targeting AAK1[J]. bioRxiv, 2025: 2025.04. 02.646796.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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