AAK1-IN-7
AAK1-IN-7 (Compound 16) is a dual AAK1/GAK inhibitor (EC50 values are 40 and 80 nM, respectively) . AAK1-IN-7 inhibits the phosphorylation of AP2-µ2 subunit at T156. AAK1-IN-7 has weak antiviral activity against RNA viruses[1].
Product Specifications
UNSPSC
12352005
Target
AAK1; Cyclin G-associated Kinase (GAK)
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Field of Research
Infection
Smiles
ClC1=CC(CNC(C2=C3C=C(C4=C5N=C(NCCOCCO3)C=CN5N=C4)C=C2)=O)=CC=C1
Molecular Formula
C24H22ClN5O3
Molecular Weight
463.92
References & Citations
[1]Mensing T E, et al. Development of pyrazolo [1, 5-a] pyrimidine based macrocyclic kinase inhibitors targeting AAK1[J]. bioRxiv, 2025: 2025.04. 02.646796.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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