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AAK1-IN-7

AAK1-IN-7 (Compound 16) is a dual AAK1/GAK inhibitor (EC50 values are 40 and 80 nM, respectively) . AAK1-IN-7 inhibits the phosphorylation of AP2-µ2 subunit at T156. AAK1-IN-7 has weak antiviral activity against RNA viruses[1].

Product Specifications

UNSPSC

12352005

Target

AAK1; Cyclin G-associated Kinase (GAK)

Related Pathways

Cell Cycle/DNA Damage; Neuronal Signaling

Field of Research

Infection

Smiles

ClC1=CC(CNC(C2=C3C=C(C4=C5N=C(NCCOCCO3)C=CN5N=C4)C=C2)=O)=CC=C1

Molecular Formula

C24H22ClN5O3

Molecular Weight

463.92

References & Citations

[1]Mensing T E, et al. Development of pyrazolo [1, 5-a] pyrimidine based macrocyclic kinase inhibitors targeting AAK1[J]. bioRxiv, 2025: 2025.04. 02.646796.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-174213/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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