MXC-017
MXC-017 is a blood-brain barrier (BBB) -penetrant apoptosis inducer that directly targets Vimentin (VIM) . MXC-017 prevents radiation-induced glioma stem cell (GSC) formation, while promoting G0/G1 cell cycle arrest and apoptosis. MXC-017 exhibits minimal off-target effects and shows no significant cytotoxicity. MXC-017 significantly prolongs median survival when used in combination with radiation therapy in glioblastoma (GBM) mouse models.
Product Specifications
CAS Number
3037024-97-5
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(NCC1=CC=C(S(=O)(N2CCCCC2)=O)C=C1)N3C4=CC=CC=C4C=C3
Molecular Formula
C21H23N3O3S
Molecular Weight
397.49
References & Citations
[1]He L, et al. Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma[J]. bioRxiv, 2025: 2025.04. 10.648292.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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