JNK-IN-23
JNK-IN-23 (Compound K12) is an inhibitor of JNK. JNK-IN-23 inhibits the proliferation of MDA-MB-231 (GIC50: 30 nM) . JNK-IN-23 blocks TNBC metastatic growth in vivo. JNK-IN-23 inhibits the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and pyruvate dehydrogenase complex (PDHC) [1].
Product Specifications
CAS Number
[1007786-48-2]
UNSPSC
12352005
Target
JNK
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Smiles
CC(C1=NC(SC(C)=C2C)=C2C(N1)=O)SC3=NC4=C(N=C3C)C=CC=C4
Molecular Formula
C19H18N4OS2
Molecular Weight
382.50
References & Citations
[1]Latham S L, et al. A selective inhibitor of oncogenic JNK signalling perturbs metastatic outgrowth of triple-negative breast cancer through metabolic blockade[J]. bioRxiv, 2025: 2025.04. 16.649243.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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