PROTAC BRD4 Degrader-31

PROTAC BRD4 Degrader-31 is a BRD4 PROTAC degrader with DC50 s of 164 and 80 nM at 4 h and 24 h, respectively. PROTAC BRD4 Degrader-31 potently degrades BRD4 in cells with long acting degradation kinetics[1]. Pink: BRD4 ligand (HY-78695) ; Blue: KLHDC2 ligand (HY-174218)

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(OC)C1=C2C(C(C3CCC4C3)C4C(C5=CC(OCCC6CCN(CC7CCN(C(C[C@@H]8N=C(C9=CC=C(Cl)C=C9)C(C(C)=C(C)S%10)=C%10N%11C8=NN=C%11C)=O)CC7)CC6)=CC=C5)N2)=CC=C1

Molecular Formula

C54H62ClN7O4S

Molecular Weight

940.63

References & Citations

[1]Zhou H, et al. Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening. bioRxiv [Preprint]. 2025 Apr 1:2025.03.31.646306.