PROTAC BRD4 Degrader-31
PROTAC BRD4 Degrader-31 is a BRD4 PROTAC degrader with DC50 s of 164 and 80 nM at 4 h and 24 h, respectively. PROTAC BRD4 Degrader-31 potently degrades BRD4 in cells with long acting degradation kinetics[1]. Pink: BRD4 ligand ; Blue: KLHDC2 ligand (HY-174218)
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(OC)C1=C2C(C(C3CCC4C3)C4C(C5=CC(OCCC6CCN(CC7CCN(C(C[C@@H]8N=C(C9=CC=C(Cl)C=C9)C(C(C)=C(C)S%10)=C%10N%11C8=NN=C%11C)=O)CC7)CC6)=CC=C5)N2)=CC=C1
Molecular Formula
C54H62ClN7O4S
Molecular Weight
940.63
References & Citations
[1]Zhou H, et al. Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening. bioRxiv [Preprint]. 2025 Apr 1:2025.03.31.646306.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
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