KLHDC2-IN-1
KLHDC2-IN-1 (Compound 6) is a ligand targeting the ubiquitin E3 ligase KLHDC2 (Kd: 160 nM) . KLHDC2-IN-1 enables the synthesis of a PROTAC that can effectively degrade BRD4 in cells[1].
Product Specifications
CAS Number
[1005275-19-3]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Others
Smiles
OC(C1=C2C(C(C3CCC4C3)C4C(C5=CC(OC(F)(F)F)=CC=C5)N2)=CC(Cl)=C1)=O
Molecular Formula
C22H19ClF3NO3
Molecular Weight
437.84
References & Citations
[1]Zhou H, et al. Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening[J]. eLife, 2025, 14: RP106844.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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