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KLHDC2-IN-1

KLHDC2-IN-1 (Compound 6) is a ligand targeting the ubiquitin E3 ligase KLHDC2 (Kd: 160 nM) . KLHDC2-IN-1 enables the synthesis of a PROTAC that can effectively degrade BRD4 in cells[1].

Product Specifications

CAS Number

1005275-19-3

UNSPSC

12352005

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Field of Research

Others

Smiles

OC(C1=C2C(C(C3CCC4C3)C4C(C5=CC(OC(F)(F)F)=CC=C5)N2)=CC(Cl)=C1)=O

Molecular Formula

C22H19ClF3NO3

Molecular Weight

437.84

References & Citations

[1]Zhou H, et al. Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening[J]. eLife, 2025, 14: RP106844.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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