2’-Oxo Ifosfamide-d4

2’-Oxo Ifosfamide-d4 is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors[1][2].

Product Specifications

CAS Number

[1329497-14-4]

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker; Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

C(CCl)(=O)N1P(NCCCl)(=O)OCC(C1([2H])[2H])([2H])[2H]

Molecular Formula

C7H9D4Cl2N2O3P

Molecular Weight

279.09

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91 (5) :357-68.|[3]Karle P, et al. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001 Mar;8 (3) :220-30.|[4]Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232 (1) :182-92.