2'-O-Methylguanosine-5'-O-triphosphate (sodium)
2'-O-Methylguanosine-5'-O-triphosphate sodium (2'-Methyl GTP sodium), a methylated derivative of Guanosine 5'-triphosphate , is a HCV NS5B RNA-dependent RNA polymerase inhibitor. 2'-O-Methylguanosine-5'-O-triphosphate sodium is a nucleotide competitor of GTP and acts as a chain terminator to inhibit RNA synthesis. 2'-O-Methylguanosine-5'-O-triphosphate sodium can be used for HCV infections research[1].
Product Specifications
Product Name Alternative
2'-Methyl GTP (sodium)
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C1NC(N)=NC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@@H](O)[C@H]3OC
Molecular Formula
C11H14N5Na4O14P3
Molecular Weight
625.13
References & Citations
[1]Dutartre H, et al. A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B. J Biol Chem. 2005 Feb 25;280 (8) :6359-68.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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