Type II TRK inhibitor 3
Type II TRK inhibitor 3 (Compound 18d) is a Type II TRK inhibitor with IC50 values of 0.82, 1.82, and 0.12 nM for TRKAWT/G595R/G667C, respectively. Type II TRK inhibitor 3 exhibits antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Trk Receptor
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=C(C#CC2=CN=C3N2C=CN=C3)C=CC=C1NC(NC4=CC(C(C)(C)C)=NN4C5=CC=CC=C5)=O
Molecular Formula
C29H27N7O
Molecular Weight
489.57
References & Citations
[1]Zhao W, et al. Discovery of novel diarylurea derivatives as potent type II TRK inhibitors for combating multiple acquired resistant mutants. Bioorg Chem. 2025 Jul 15;162:108590.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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