MerTK-IN-2
MerTK-IN-2 (compound 15f) is an orally active MerTK inhibitor with an IC50 of 37.5 nM. MerTK-IN-2 can induce apoptosis. MerTK-IN-2 has antitumor activity with IC50 values of 1.79, 18.32, and 2.18 μM for human ovarian cancer cells A2780, breast cancer cells MDA-MB-231, and colon cancer cells HCT116, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; TAM Receptor
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
FC(C=C1)=CC=C1NC2=NC(NC3CCC(O)CC3)=C(C4=CC=CC(C#N)=N4)C=N2
Molecular Formula
C22H21FN6O
Molecular Weight
404.44
References & Citations
[1]Yang J, et al. Design, synthesis, and biological evaluation of novel 2-substituted aniline pyrimidine derivatives as potential and orally bioavailable Mer inhibitors with antitumor activities. Bioorg Chem. 2025 Jul 15;162:108591.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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