COX-2-IN-54

COX-2-IN-54 (Compound 7y) is an orally active COX-2 inhibitor with an IC50 of 4.15 μM. COX-2-IN-54 has a strong protective effect against DSS-induced ulcerative colitis and can significantly reduce tissue damage. COX-2-IN-54 has anti-inflammatory activity[1].

Product Specifications

UNSPSC

12352005

Target

COX

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C1N(C2=CC=C(CC(O)=O)C=C2)C(NC(CCCl)=O)C3=CC=CC=C31

Molecular Formula

C19H17ClN2O4

Molecular Weight

372.80

References & Citations

[1]Lai H, Liang Y, Xu J, Guo L, Deng C, Wang X, Zha D. Converting indoprofen to moderate selective COX-2 inhibitors: Design, synthesis and biological evaluation. Bioorg Chem. 2025 Jul 15;162:108593.