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HDAC6-IN-59

HDAC6-IN-59 (Compound 38k) is a highly selective histone deacetylase 6 (HDAC6) inhibitor (IC50=3.12 nM, with 352-fold selectivity over HDAC1) . HDAC6-IN-59 is promising for research of esophageal cancer[1].

Product Specifications

CAS Number

2998932-98-0

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(C1=CC=C(CNC2=NC(C3=CC=C(C=C3)Cl)=NN2C4=CC=CC=C4)C=C1)NO

Molecular Formula

C22H18ClN5O2

Molecular Weight

419.86

References & Citations

[1]Zhang X, et al. Structural Optimization of 1,3-Diaryl-1,2,4-triazole-Capped Histone Deacetylase 6 Inhibitors to Obtain Novel Antiesophageal Cancer Candidates. J Med Chem. 2025 Jun 12;68 (11) :10991-11016.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC6

Frequently Asked Questions

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