Anion transporter-4
Anion transporter-4 (Compound 6) is a small-molecule anion transporter, which induces tubulin degradation and mitochondrial dysfunction. Anion transporter-4 can increase intracellular anion levels such as chloride ions by disrupting microtubule dynamics, promoting lipid peroxidation, and impairing mitochondrial function. Anion transporter-4 triggers ferroptosis to exert anticancer activity. Anion transporter-4 is promising for research of cancers[1].
Product Specifications
UNSPSC
12352005
Target
Anion Exchangers; Ferroptosis
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
FC1=CC(C2=NC3=C(C=C(C(F)(F)F)C=C3C(F)(F)F)N2)=CC(C4=NC5=C(C=C(C(F)(F)F)C=C5C(F)(F)F)N4)=C1
Molecular Formula
C24H9F13N4
Molecular Weight
600.33
References & Citations
[1]Hong XQ, et al. Ferroptosis of Cancer Cells via Tubulin Degradation and Mitochondrial Dysfunction: A Novel Mechanism of Anticancer Effect for Small-Molecule Anion Transporters. J Med Chem. 2025 Jun 12;68 (11) :10970-10990.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC880460-100 1x 100 µL
CD44 Standard (156-3C11), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040994-500 1x 500 µL
TNF alpha (J2D10), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940178-100 1x 100 µL
CD50 (ICAM-3) (186-2G9), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040665-500 1x 500 µL
Smooth Muscle Actin (1A4), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 