RJG-2036

RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2) (IC50=100 nM) . RJG-2036 inhibits NADPH-dependent reduction, significantly reducing secretion of proinflammatory cytokines like TNF-α and multiple eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 is promising for research of inflammatory diseases[1].

Product Specifications

CAS Number

[2851993-73-0]

UNSPSC

12352005

Target

Prostaglandin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Smiles

O=C(N1CCN(CC1)C2=C(OC)C=CC=C2)C3=CC=CC(S(=O)(N4N=CN=C4)=O)=C3

Molecular Formula

C20H21N5O4S

Molecular Weight

427.48

References & Citations

[1]Founds MW, et al. Human PTGR2 Inactivation Alters Eicosanoid Metabolism and Cytokine Response of Inflammatory Macrophages. ACS Chem Biol. 2025 May 19.