EXO1-IN-1

EXO1-IN-1 (Compound F684) is a potent and selective inhibitor of exonuclease 1 (EXO1) (IC50= 15.7 μM) . EXO1-IN-1 suppresses DNA end resection, promotes the accumulation of DNA double-strand breaks, and triggers S-phase PARylation, disrupts DNA repair pathways in homologous recombination-deficient (HRD) cancer cells, and selectively kills tumor cells with defects in HR genes like BRCA1/2. EXO1-IN-1 is promising for research of homologous recombination-deficient cancer (such as BRCA-related tumors) [1].

Product Specifications

CAS Number

[1111188-09-0]

UNSPSC

12352100

Target

Others

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=C(N2CCN(C3=CC=C(NS(=O)(C4=CC=CC=C4)=O)C(C(O)=O)=C3)CC2)C=CC=C1C

Molecular Formula

C25H27N3O4S

Molecular Weight

465.56

References & Citations

[1]Wang Y, et al. Discovery and Characterization of Small Molecule Inhibitors Targeting Exonuclease 1 for Homologous Recombination-Deficient Cancer Therapy. ACS Chem Biol. 2025 May 16.