LP-65
LP-65 is a dual inhibitor of MEK (IC50=83.2 nM) and mTOR (IC50=40.5 nM) . LP-65 blocks MEK and mTOR signaling pathways and inhibits tumor cell proliferation and migration. LP-65 is promising for research of cancers[1].
Product Specifications
UNSPSC
12352005
Target
MEK; mTOR
Related Pathways
MAPK/ERK Pathway; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
FC1=C(F)C(NC2=C(F)C=C(I)C=C2)=C(C(NOCCOCCOCCOCCC(OCC3=CC(C4=CC=C(C(N5CCOC[C@@H]5C)=NC(N6CCOC[C@@H]6C)=N7)C7=N4)=CC=C3OC)=O)=O)C=C1
Molecular Formula
C47H53F3IN7O10
Molecular Weight
1059.86
References & Citations
[1]Van Dort ME, et al. Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents. J Med Chem. 2025 Jun 12;68 (11) :11406-11418.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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