VU0514009

VU0514009 is a competitive chemokine-like receptor 1 (CMKLR1) antagonist (EC50=2 nM) . VU0514009 prevents chemerin-9-induced arrestin recruitment and receptor internalization, significantly reducing Ca2+ flux response in HEK293 cells. VU0514009 is promising for research of inflammatory diseases and metabolic syndrome[1].

Product Specifications

CAS Number

[932973-77-8]

UNSPSC

12352005

Target

Chemerin Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

O=C1C(S(C2=CC=C(C(Cl)=C2)C)(=O)=O)=CNC(SCC(NC3=CC(C)=CC=C3OC)=O)=N1

Molecular Formula

C21H20ClN3O5S2

Molecular Weight

493.98

References & Citations

[1]Schermeng T, et al. Similar Binding Mode of a 5-Sulfonylthiouracil Derivative Antagonist at Chemerin Receptors CMKLR1 and GPR1. J Med Chem. 2025 Jun 12;68 (11) :11149-11173.