VU0514009
VU0514009 is a competitive chemokine-like receptor 1 (CMKLR1) antagonist (EC50=2 nM) . VU0514009 prevents chemerin-9-induced arrestin recruitment and receptor internalization, significantly reducing Ca2+ flux response in HEK293 cells. VU0514009 is promising for research of inflammatory diseases and metabolic syndrome[1].
Product Specifications
CAS Number
932973-77-8
UNSPSC
12352005
Target
Chemerin Receptor
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C1C(S(C2=CC=C(C(Cl)=C2)C)(=O)=O)=CNC(SCC(NC3=CC(C)=CC=C3OC)=O)=N1
Molecular Formula
C21H20ClN3O5S2
Molecular Weight
493.98
References & Citations
[1]Schermeng T, et al. Similar Binding Mode of a 5-Sulfonylthiouracil Derivative Antagonist at Chemerin Receptors CMKLR1 and GPR1. J Med Chem. 2025 Jun 12;68 (11) :11149-11173.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ChemR23/CMKLR1
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