CMKLR1 antagonist 2

CMKLR1 antagonist 2 (compound 16) is a full and competitive chemerin/chemokine-like receptor 1 (CMKLR1) antagonist with an IC50 of 37 μM. CMKLR1 antagonist 2 can be used for study of inflammation[1].

Product Specifications

UNSPSC

12352100

Target

CCR

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C1C(S(C2=CC=C(C(Cl)=C2)C)(=O)=O)=CNC(SCC(NC3=CC=C(C=C3)C(F)(F)F)=O)=N1

Molecular Formula

C20H15ClF3N3O4S2

Molecular Weight

517.93

References & Citations

[1]Schermeng T, et al. Similar Binding Mode of a 5-Sulfonylthiouracil Derivative Antagonist at Chemerin Receptors CMKLR1 and GPR1. J Med Chem. 2025 Jun 12;68 (11) :11149-11173.