FLT3-IN-31

FLT3-IN-31 (compound 10q) is a potent FLT3 inhibitor with IC50 values of 0.16, 2.4 nM for FLT3, FLT3-D835Y, resprctively. FLT3-IN-31 shows antiproliferation activity. FLT3-IN-31 decreases the protein expression of p-FLT3, P-STAT5, P-ERK. FLT3-IN-31 induces apoptosis and cell cycle arrest at G1 phase. FLT3-IN-31 shows antitumor activity[1].

Product Specifications

CAS Number

[2290545-53-6]

UNSPSC

12352005

Target

Apoptosis; FLT3

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

NC1=NC=CC(C2=CC=C3C(NN=C3/C=C/C4=CC=C(C(F)=C4)CN5CCOCC5)=C2)=C1

Molecular Formula

C25H24FN5O

Molecular Weight

429.49

References & Citations

[1]Liu Z, et al. Discovery of a Potent FLT3 Inhibitor (E) -4- (3- (3-Fluoro-4- (morpholinomethyl) styryl) -1H-indazol-6-yl) pyridin-2-amine for the Treatment of Acute Myeloid Leukemia with Multiple FLT3 Mutations. J Med Chem. 2025 Jun 12;68 (11) :11894-11915.