STING Degrader-2
STING Degrader-2 (Compound SI-43) is a STING inhibitor and mutant-specific degrader. STING Degrader-2 can effectively inhibit cGAMP-induced STING activation and significantly reduce the release of IFN-β and CXCL-10. It inhibits the activity of STING by binding to two pockets of the STING dimer and induces proteasome-independent degradation of mutants STING S154 and STING M155 (DC50 values are 0.31 and 0.76 μM, respectively) . STING Degrader-2 can be used to study STING-related autoimmune diseases[1].
Product Specifications
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=CC(NS(=O)(C)=O)=C(O)C=C1)C2=CC=C(C3=CC4=C(C=C3)OC(C(C(C(N)=O)C5=C6C=C(OC)C=C5)N(C7=CC(F)=C(C(C)(C)C)C=C7)C6=O)=C4)C=C2
Molecular Formula
C43H39FN4O8S
Molecular Weight
790.86
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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