HSD17B13-IN-104
HSD17B13-IN-104 (Compound 32) is an orally active, highly potent and selective HSD17B13 inhibitor (IC50=2.5 nM) . HSD17B13-IN-104 regulates hepatic lipid metabolism by inhibiting the SREBP-1c/FAS pathway. HSD17B13-IN-104 blocks HSD17B13 enzymatic activity to improve hepatic lipid accumulation. HSD17B13-IN-104 is promising for research of metabolic dysfunction-associated steatohepatitis[1].
Product Specifications
CAS Number
[3075100-76-1]
UNSPSC
12352100
Target
17β-HSD
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Purity
95.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)N=C(S1)C2=CC(F)=C(F)C(O)=C2F)N(C(C)C)CC3=CC=C(C=C3)Cl
Molecular Formula
C21H18ClF3N2O2S
Molecular Weight
454.89
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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