CW8001
CW8001 is a covalent XPO1 (Exportin-1) inhibitor with an EC50 value of 1 nM for inhibiting T cell activation. CW8001 prevents nuclear localization of NFAT transcription factors, suppressing expression of inflammatory cytokines like IL-2. CW8001 is promising for research of T cell-driven immune diseases such as graft-versus-host disease (GVHD) [1].
Product Specifications
UNSPSC
12352005
Target
CRM1
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Smiles
O=C1C(C)=CC(N1NC2=NC(C(F)(F)F)=NN3C2=CC=C3)=O
Molecular Formula
C12H8F3N5O2
Molecular Weight
311.22
References & Citations
[1]Shen Y, et al. XPO1-Targeting Selective Inhibitors of Transcriptional Activation Suppress Graft-versus-Host Disease. J Med Chem. 2025 Jun 12;68 (11) :12141-12171.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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