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PI4Kβ/PKG-IN-1

PI4Kβ/PKG-IN-1 (Compound 19) is an orally active dual inhibitor targeting Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG) . PI4Kβ/PKG-IN-1 exhibits potent antiplasmodial activity. PI4Kβ/PKG-IN-1 is promising for research of malaria[1].

Product Specifications

UNSPSC

12352005

Target

Parasite; PI4K; PKG

Related Pathways

Anti-infection; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Infection

Smiles

NC1=NC2=CC(C3=NN(CC4=CC=C(Cl)C(F)=C4)C5=NC=NC(N)=C53)=CC=C2O1

Molecular Formula

C19H13ClFN7O

Molecular Weight

409.80

References & Citations

[1]Gachuhi S, et al. Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria. J Med Chem. 2025 Jun 12;68 (11) :10757-10770.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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