Multi-target kinase-IN-5

Multi-target kinase-IN-5 (Compound 23) is an orally active ERK1/2 inhibitor (IC50 values are 3.04 nM and 1.57 nM, respectively) . Multi-target kinase-IN-5 significantly inhibits cancer cell proliferation, migration and invasion, and induces cell apoptosis and cell cycle arrest. Multi-target kinase-IN-5 inhibits the phosphorylation of ERK1/2 and downregulates the activity of its downstream substrate RSK to exert anti-tumor effects. Multi-target kinase-IN-5 can be used in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; ERK

Related Pathways

Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(C1=CC2=C(C=C1)C=NC(NC3COC3)=N2)N[C@H](CO)C4=CC=C(C(F)=C4)Cl

Molecular Formula

C20H18ClFN4O3

Molecular Weight

416.83

References & Citations

[1]Zhang P, et al. Discovery of 2-Amino-7-Amide Quinazoline Derivatives as Potent and Orally Bioavailable Inhibitors Targeting Extracellular Signal-Regulated Kinase 1/2. J Med Chem. 2025 Jun 12;68 (11) :12204-12228.