P2Y1 antagonist 3

P2Y1 antagonist 3 (compound 36b) is a blood-brain barrier (BBB) -penetrant P2Y1 antagonist with an IC50 of 0.50 μM. P2Y1 antagonist 3 exhibits protective effects in a rat middle cerebral artery occlusion (MCAO) model and demonstrates neuroprotective activity against oxidative stress by upregulating nuclear Nrf2 protein levels[1].

Product Specifications

UNSPSC

12352005

Target

P2Y Receptor

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Smiles

OC(C1=CN=C(C2=CC=CC(C#N)=C2)N=C1OC3=CC=CC(C#N)=C3)=O

Molecular Formula

C19H10N4O3

Molecular Weight

342.31

References & Citations

[1]Zhang B, et al. Design, Synthesis, and Biological Evaluation of 4- (Difluoromethyl) -1H-imidazole-5-carboxylic Acids/4- (3-Cyanophenoxy) pyrimidine-5-carboxylic Acids as P2Y1 Receptor Antagonists for Ischemic Stroke Treatment. J Med Chem. 2025 Jun 12;68 (11) :10930-10952.