Thalidomide-4-OH-C11-OH
Thalidomide-4-OH-C11-OH is an E3 Ligase Ligand-Linker Conjugate, which is composed of Thalidomide-4-OH and the corresponding Linker. Thalidomide-4-OH-C11-OH can be used as a Cereblon ligand to recruit CRBN protein and as a key intermediate for the synthesis of complete PROTACs molecules, such as PROTAC GPX4 degrader-4 (HY-174086).
Product Specifications
CAS Number
3071165-50-6
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N(C(C2=C(C=CC=C21)OCCCCCCCCCCCO)=O)C3CCC(NC3=O)=O
Molecular Formula
C24H32N2O6
Molecular Weight
444.52
References & Citations
[1]Yang X, et al. Discovery of Artesunate (ARS) PROTACs as GPX4 protein degraders for the treatment of bladder cancer. Eur J Med Chem. 2025 Sep 5;293:117710.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC681429-500 1x 500 µL
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401073-500 1x 500 µL
HLA-Aw32 & HLA-A25 (MHC I) (CATA-1), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400676-100 1x 100 µL
MUC18 / Mucin 18 / CD146 (OJ79c), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471104-100 1x 100 µL
PAX2 (Renal Cell & Ovarian Carcinoma Marker) (PAX2/1104), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401593-500 1x 500 µL
Aurora B (Proliferation Marker) (AURKB/1593), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC742078-100 1x 100 µL
TCL1 (T-Cell Marker) (TCL1/2078), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details