SI-W052

SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targeting mTOR and TEX264. SI-W052 activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6) . SI-W052 is promising for research of Alzheimer’s disease (AD) -associated neuroinflammation[1].

Product Specifications

CAS Number

[2572552-60-2]

UNSPSC

12352005

Target

Autophagy; Interleukin Related; mTOR

Related Pathways

Autophagy; Immunology/Inflammation; PI3K/Akt/mTOR

Field of Research

Inflammation/Immunology; Neurological Disease

Purity

98.0

Smiles

O=S(N(C)CC1=CC=CC=C1)(C2=C(Cl)C=C(NCC3=CC=CO3)C(C(O)=O)=C2)=O

Molecular Formula

C20H19ClN2O5S

Molecular Weight

434.89

References & Citations

[1]Wang Z, et al. Anti-Inflammatory Anthranilate Analogue Enhances Autophagy through mTOR and Promotes ER-Turnover through TEX264 during Alzheimer-Associated Neuroinflammation. ACS Chem Neurosci. 2022 Feb 2;13 (3) :406-422.