β-Glu-PAB (CH2NH2) -Exatecan
β-Glu-PAB (CH2NH2) -Exatecan (Compound 9a) is a topoisomerase I inhibitor. β-Glu-PAB (CH2NH2) -Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. β-Glu-PAB (CH2NH2) -Exatecan can be specifically cleaved by β-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. β-Glu-PAB (CH2NH2) -Exatecan is also an intermediate of Mal ((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12) -β -Glu-Pab-Exatecan. β-Glu-PAB (CH2NH2) -Exatecan is promising for research of cancers[1].
Product Specifications
CAS Number
[3025108-11-3]
UNSPSC
12352203
Target
Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
96.60
Solubility
DMSO : 100 mg/mL
Smiles
NCC(C=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=C(C=C1)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O
Molecular Formula
C39H39FN4O13
Molecular Weight
790.74
References & Citations
[1]krishna BAJJURI, et al. β-GLUCURONIDE LINKER-PAYLOADS, PROTEIN CONJUGATES THEREOF, AND METHODS THEREOF. WO2024006272A1. 2024-09-26.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Topoisomerase
Available Sizes
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