RBN012811
RBN012811 is a selectively PARP14 PROTAC degrader with a DC50 of 5 nM in KYSE-270 cells. RBN012811 significantly decreases IL-10 expression in IL-4 stimulated macrophages[1]. Pink: PARP14 ligand (HY-150947) ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker
Product Specifications
CAS Number
[2569517-30-0]
UNSPSC
12352005
Target
Interleukin Related; PARP; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; PROTAC
Field of Research
Cancer
Purity
98.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N=C(CSC2CCN(CC2)CC(NCCCCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)NC6=CC(NC7CCCC7)=CC(F)=C16
Molecular Formula
C40H49FN8O6S
Molecular Weight
788.93
References & Citations
[1]Wigle TJ, et al. Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule. Chembiochem. 2021 Jun 15;22 (12) :2107-2110.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-10; PARP14
Available Sizes
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