Clozapine N-oxide (Standard)
Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
Product Specifications
UNSPSC
12352005
Hazard Statement
H301, H336
Target
Dopamine Receptor; Drug Metabolite; mAChR; Reference Standards
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease
Purity
99.78
Smiles
[O-][N+]1(C)CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1
Molecular Formula
C18H19ClN4O
Molecular Weight
342.82
Precautions
H301, H336
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17366R/Clozapine-N-oxide-Standard-SDS-MedChemExpress.pdf
Scientific Category
Reference Standards
CAS Number
[34233-69-7]
Available Sizes
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