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NCGC00238624

NCGC00238624 is a selective galactokinase (GALK1) inhibitor with IC50s of 7.69 μM and 13.67 μM against the human and mouse recombinant GALK1, respectively. NCGC00238624 is inactive against GALK2 and other kinases at 10 μM. NCGC00238624 can be used for the study of classic galactosemia[1].

Product Specifications

CAS Number

2768230-55-1

UNSPSC

12352005

Target

Galactokinase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C1C2=C(CCC1)NC(NC3=NC4=CC=CC=C4O3)=N[C@H]2C5=NNC=C5Cl

Molecular Formula

C18H15ClN6O2

Molecular Weight

382.80

References & Citations

[1]Liu L, et al. Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J Med Chem. 2021 Sep 23;64 (18) :13551-13571.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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