NCGC00238624
NCGC00238624 is a selective galactokinase (GALK1) inhibitor with IC50s of 7.69 μM and 13.67 μM against the human and mouse recombinant GALK1, respectively. NCGC00238624 is inactive against GALK2 and other kinases at 10 μM. NCGC00238624 can be used for the study of classic galactosemia[1].
Product Specifications
CAS Number
[2768230-55-1]
UNSPSC
12352005
Target
Galactokinase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C1C2=C(CCC1)NC(NC3=NC4=CC=CC=C4O3)=N[C@H]2C5=NNC=C5Cl
Molecular Formula
C18H15ClN6O2
Molecular Weight
382.80
References & Citations
[1]Liu L, et al. Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J Med Chem. 2021 Sep 23;64 (18) :13551-13571.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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