MNN-02-155
MNN-02-155 is a bivalent molecular glue with with dual binding to p300/CBP and BCL6. MNN-02-155 induces potent activation of the BCL6-target reporter gene and cell death. MNN-02-155 can be used for the study of diffuse large B cell lymphomas (DLBCLs) [1].
Product Specifications
CAS Number
[3067681-22-2]
UNSPSC
12352005
Target
BCL6; Histone Acetyltransferase; Molecular Glues
Related Pathways
Epigenetics; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N1CC2=C(CC1)N(C3CCN(CC3)C(CCCCNC(C4CCN(CC4)C5=NC=C(C(NC6=CC(C=C(C(N7C)=O)OCC(NC)=O)=C7C(OC)=C6)=N5)Cl)=O)=O)N=C2N8C9=C(CCC8)C=C(C%10=CN(C)N=C%10)C(C(F)F)=C9)NC
Molecular Formula
C56H68ClF2N15O7
Molecular Weight
1136.69
References & Citations
[1]Nix MN, et al. A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death. bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.643404.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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