ID11916
ID11916 is an orally active androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. ID11916 blocks androgen binding to AR, nuclear translocation, and androgen-dependent transcriptional activity of AR, while increasing intracellular cGMP levels and activating PKG via inhibition. ID11916 shows potent anti-cancer effect in prostate cancer cell lines VCaP and 22Rv1 and in AR-positive breast cancer cell lines SK-BR-3[1].
Product Specifications
CAS Number
2785317-21-5
UNSPSC
12352005
Target
Androgen Receptor; Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C(C)(N(C(N1C2=CN=C(C(C(F)(F)F)=C2)C#N)=S)C3=CC=C(C(C4=NN5C(C(N4)=O)=C(N=C5CCC)C)=C3)OCC)C
Molecular Formula
C29H27F3N8O3S
Molecular Weight
624.64
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE5
Frequently Asked Questions
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