Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB
Selected Variant
HY-173635
Size: 1 Each
Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB is an interchain cysteines to a Maleimide-reactive, β-glucuronidase-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as AZD0516.
Product Specifications
UNSPSC
12352203
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(O)OCC1=CC=C(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)C(CNC(CCNC([C@@H](NC(CCN3C(C=CC3=O)=O)=O)CCCC(N[C@@H]4[C@@H](OC[C@@H]5NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)[C@@H]5OC4)=O)=O)=O)=C1
Molecular Formula
C63H98N6O31
Molecular Weight
1435.47
References & Citations
[1]Darlene Monlish, et al. Abstract 1158: Preclinical characterization of AZD0516, a novel STEAP2 antibody-drug conjugate (ADC) for the treatment of prostate cancer. Cancer Res (2025) 85 (8_Supplement_1) : 1158.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Price
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