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Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB-Exatecan

Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB-Exatecan (LP1) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan and a linker Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB (HY-173635) to make antibody agent conjugate (ADC), AZD0516 (HY-173639).

Product Specifications

CAS Number

3059991-66-8

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

96.11

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC(OCC7=CC=C(O[C@@H]8O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]8O)C(CNC(CCNC([C@@H](NC(CCN9C(C=CC9=O)=O)=O)CCCC(N[C@@H]%10[C@@H](OC[C@@H]%11NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)[C@@H]%11OC%10)=O)=O)=O)=C7)=O)C(C)=C(F)C=C6N=C4C3=C2)=O

Molecular Formula

C87H118FN9O34

Molecular Weight

1852.91

References & Citations

[1]Asurayya WORREDE, et al. Steap2 antibody drug conjugates and uses thereof. WO2024214028A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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