Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB-Exatecan
Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB-Exatecan (LP1) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan and a linker Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB (HY-173635) to make antibody agent conjugate (ADC), AZD0516 (HY-173639).
Product Specifications
CAS Number
3059991-66-8
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
96.11
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
Molecular Formula
C87H118FN9O34
Molecular Weight
1852.91
References & Citations
[1]Asurayya WORREDE, et al. Steap2 antibody drug conjugates and uses thereof. WO2024214028A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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