(S) -dHTC1
(S) -dHTC1 is a molecular glue degrader targeting the transcriptional co-activator ENL. (S) -dHTC1 binds the ligase with high affinity only after forming the ENL:dHTC1 complex with an IC50 value of 93 nM. (S) -dHTC1 degrades ENL in MV4;11 cells with a DC50 value of 26 nM. (S) -dHTC1 can be used for acute myeloid leukemia study[1].
Product Specifications
CAS Number
3081383-46-9
UNSPSC
12352005
Target
PROTACs
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC1CCC1)C(C=C2)=CN(C2=N3)C=C3C4=CC=CC(C(NCCN5CCC(NS(=O)(N6C[C@@]7(CC(NC7=O)=O)CC6)=O)CC5)=O)=C4
Molecular Formula
C33H40N8O6S
Molecular Weight
676.79
References & Citations
[1]JB Shaum, et al. High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity. bioRxiv. September 30, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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