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(Rac) -BMS-986449

(R) -BMS-986449 is the racemic mixture of BMS-986449. BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors[1].

Product Specifications

UNSPSC

12352005

Target

IKZF Family; Molecular Glues

Related Pathways

Immunology/Inflammation; PROTAC

Field of Research

Cancer

Purity

99.05

Smiles

NC1=NC(C2=C(C(C(N3C4CCC(NC4=O)=O)C)=C(C=C2)C3=O)F)=CC(C)=C1C

Molecular Formula

C21H21FN4O3

Molecular Weight

396.41

References & Citations

[1]Barnes M J. Selective degradation of Helios induces Treg cell reprogramming and enhanced antitumor immunity[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 2249-2249.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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