BMS-986449
BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors[1].
Product Specifications
UNSPSC
12352005
Target
IKZF Family; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC1=NC(C2=C(F)C([C@@H](C)N([C@H]3CCC(NC3=O)=O)C4=O)=C4C=C2)=CC(C)=C1C
Molecular Formula
C21H21FN4O3
Molecular Weight
396.41
References & Citations
[1]Barnes M J. Selective degradation of Helios induces Treg cell reprogramming and enhanced antitumor immunity[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 2249-2249.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
IKZF2; IKZF4
Available Sizes
Curated Selection
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