(R, S, S) -VH032-Me
(R, S, S) -VH032-Me is a ligand for E3 ubiquitin ligase. (R, S, S) -VH032-Me can be connected to the ligand for protein by a linker to form dTAGV-1-NEG (HY-145514A) . PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
Product Specifications
CAS Number
[1948273-05-9]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
N[C@H](C(N1[C@H](C[C@@H](C1)O)C(N[C@@H](C)C2=CC=C(C=C2)C3=C(N=CS3)C)=O)=O)C(C)(C)C
Molecular Formula
C23H32N4O3S
Molecular Weight
444.59
References & Citations
[1]Nabet B, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11 (1) :4687.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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