P5 (PEG12) -VC-PAB-Exatecan
P5 (PEG12) -VC-PAB-Exatecan (LP3) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan and a linker P5 (PEG24) -VC-PAB to make antibody agent conjugate (ADC). P5 (PEG12) -VC-PAB-Exatecan can be used for the research of tumor[1].
Product Specifications
CAS Number
2928571-52-0
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C1)=CC=C1COC(N[C@H]2CCC3=C4C2=C5C(C(N6C5)=CC([C@](CC)(O)C(OC7)=O)=C7C6=O)=NC4=CC(F)=C3C)=O)=O)=O)C8=CC=C(NP(C#C)(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O)C=C8
Molecular Formula
C76H103FN9O24P
Molecular Weight
1576.65
References & Citations
[1]Schmitt S, et al. Design and evaluation of phosphonamidate-linked exatecan constructs for highly loaded, stable, and efficacious Antibody-Drug-Conjugates. Mol Cancer Ther. 2023 Oct 12.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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