TE-11

TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. TE-11 ameliorates CD-like colitis, reduces MIF-induced eosinophil and neutrophil migration, and prevents M1 polarization and associated metabolic reprogramming[1].

Product Specifications

CAS Number

[160488-11-9]

UNSPSC

12352005

Target

Macrophage migration inhibitory factor (MIF)

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C1C2=CC=CC=C2CC/C1=C\C3=NC=CC=C3

Molecular Formula

C16H13NO

Molecular Weight

235.28

References & Citations

[1]Eszter Vámos, MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn's disease-like colitis in male mice. Front Immunol. 2025 Apr 22:16:1558079.