EU 1622-240
EU 1622-240 is a biased positive allosteric modulator of GluN2B, GluN2C, and GluN2D, with EC50s of 0.57, 0.82, 1.1 μM respectively. EU 1622-240 has good physicochemical properties, in vitro stability, and permeability[1].
Product Specifications
CAS Number
3057728-22-7
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
C#CC1=C(C2=C(N=CN(C2=O)CC(N3CC(F)(C3)C)=O)S1)C4=CC=C(C(Br)=C4)F
Molecular Formula
C20H14BrF2N3O2S
Molecular Weight
478.31
References & Citations
[1]Fritzemeier RG, et al. Thienopyrimidinone Derivatives as a GluN2B/C/D Biased, Positive Allosteric Modulator of the N-Methyl-d-Aspartate Receptor. J Med Chem. 2025 May 8;68 (9) :9303-9322.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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