PPARγ modulator-4
PPARγ modulator-4 (Compound (I) ) is a PPARγ inhibitor (KD: 3.75 μM) . PPARγ modulator-4 can inhibit CDK5-mediated phosphorylation of PPARγ at Ser245. PPARγ modulator-4 can be used in insulin resistance research[1].
Product Specifications
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Smiles
O=C1OC(C(C2=CC=C(C=C2)Br)=C1O)C3=CC=CC(O)=C3
Molecular Formula
C16H11BrO4
Molecular Weight
347.16
References & Citations
[1]Cazzaniga G, et al. Enhancing the activity of γ-hydroxy lactone derivatives as innovative peroxisome proliferator-activated receptor γ non-agonists inhibiting cyclin-dependent kinase 5-mediated phosphorylation. Eur J Med Chem. 2025 Aug 5;292:117657.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ
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