PPARγ modulator-4

PPARγ modulator-4 (Compound (I) ) is a PPARγ inhibitor (KD: 3.75 μM) . PPARγ modulator-4 can inhibit CDK5-mediated phosphorylation of PPARγ at Ser245. PPARγ modulator-4 can be used in insulin resistance research[1].

Product Specifications

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease

Smiles

O=C1OC(C(C2=CC=C(C=C2)Br)=C1O)C3=CC=CC(O)=C3

Molecular Formula

C16H11BrO4

Molecular Weight

347.16

References & Citations

[1]Cazzaniga G, et al. Enhancing the activity of γ-hydroxy lactone derivatives as innovative peroxisome proliferator-activated receptor γ non-agonists inhibiting cyclin-dependent kinase 5-mediated phosphorylation. Eur J Med Chem. 2025 Aug 5;292:117657.