Aβ1–42 aggregation inhibitor 3
Aβ1–42 aggregation inhibitor 3 (Compound 3b) is an acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor (IC50 values are 1.634 and 0.0285 μM, respectively) . Aβ1–42 aggregation inhibitor 3 can inhibit the aggregation of Aβ1-42. Aβ1–42 aggregation inhibitor can be used in Alzheimer's disease (AD) research[1].
Product Specifications
CAS Number
[32527-84-7]
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
NC1=C(SC2=CC=C([N+]([O-])=O)C=C2)C(C)=NN1C3=CC=CC=C3
Molecular Formula
C16H14N4O2S
Molecular Weight
326.37
References & Citations
[1]Rani P, et al. Design and development of sulfenylated 5-aminopyrazoles as inhibitors of acetylcholinesterase and butyrylcholinesterase: exploring the implication for Aβ1-42 aggregation inhibition in Alzheimer's disease. RSC Med Chem. 2025 Apr 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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